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Advancing IPF Diagnostics and Treatment Efforts with Collagen Hybridizing Peptides
At 3Helix, our research has delved into the utilization of Collagen Hybridizing Peptides (CHPs) to discern between inflamed and normal lung cells, mirroring the fibroblast dysfunction observed in idiopathic pulmonary fibrosis (IPF). The complexities of IPF pose large challenges in both its diagnosis and treatment. It is frequently identified at advanced stages of fibrosis or misdiagnosed altogether due to the vague and overlapping nature of its symptoms with other pulmonary conditions. Regrettably, available treatments slow fibrotic progression without addressing its root cause.
In this landscape, CHPs can solve these issues. By selectively binding to fibrotic tissue, they hold promise in facilitating earlier and more accurate diagnoses of IPF, enabling clinicians to intervene at more opportune junctures and potentially mitigate disease progression. Additionally, in IPF and other pulmonary conditions, collagen is excessively deposited onto critical barriers including alveolar walls and the pleura, which over time inhibits alveolar gas exchange the lung's ability to expand and contract.
Collagen Hybridizing Peptides also hold promise to investigate post-COVID pulmonary fibrosis, as clinicians note that IPF develops more frequently in ARDS resulting from COVID than other sources.
We believe that our In Vivo CHPs represent a valuable resource for researchers and clinicians alike, providing a powerful tool for investigating the intricate mechanisms underlying these conditions and advancing our collective understanding of pulmonary fibrosis and related disorders.
CHPs are a valuable tool in detecting and understanding development in IPF and many other conditions such as:
We highly recommend using our B-CHPs or In Vivo CHPs to investigate these conditions
Our In Vivo CHPs are conjugated with sCy 7.5 for near-IR detection, and our B-CHP is conjugated with Biotin for Avidin/Streptavidin-mediated targeting.
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