Pancreatic Ductal Adenocarcinoma (PDAC) - 3Helix, Inc. – 3Helix Inc

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Pancreatic Ductal Adenocarcinoma (PDAC)

Table of Contents

Introduction
Current Treatment Challenges
Why CHPs?

Fibrotic Tumors in a Clinical Array of PDAC can be Selectively Identified and Monitored by Collagen Hybridizing Peptides

Pancreatic Ductal Adenocarcinoma (PDAC) poses a wide range of diagnosis and treatment challenges. First, PDAC is difficult to diagnose; by the time patients present symptoms, they most likely have an advanced form of the disease, and the diagnosis is typically fatal. Furthermore, PDAC symptoms are not specific, meaning the condition is often misdiagnosed.

PDAC, like some other cancers, is characterized by the fibrotic shell which fibroblasts create around the tumor, "hiding" the tumor from the immune system, detection methods, and some therapies. Collagen Hybridizing Peptides can target and visualize this fibrotic shell, keeping researchers more informed about the how PDAC progresses and giving them the ability to make earlier, life-saving diagnoses.

We have already shown that CHPs can target and identify fibrosis significantly faster and with more detail than alternative stains, and can recognize the disease at every stage including metastasis.

Such fluorescent staining could be useful in other lethal malignancies:

Lung Cancer
Ovarian Cancer
Liver Cancer
Intrahepatic bile duct cancer
Esophageal cancer
Actue Myeloind leukemia
Stomach Cancer

We highly recommend using our In Vivo CHPs to investigate these conditions

In Vivo Probes R-CHP

Our R-CHP is Conjugated with Cy3. Contact us for customized conjugates.

Understanding Pancreatic Ductal Adenocarcinoma

Understanding PDAC

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of pancreatic neoplasm, stemming from the lack of an early diagnosis and limited response to treatments. PDAC is developed in the exocrine compartment, and has extremely high heterogeneity. Symptoms include tumors, weight loss, abdominal pain, and jaundice. Despite scientific progress, PDAC has an average 5-year survival rate of less than 10%, and is expected to become one of the top leading causes of cancer-related mortality.

Current Treatment Challenges

The current standard of care for PDAC includes surgery, chemotherapy, radiation, and palliative therapy. Unfortunately, the lack of an early diagnosis allows tumors to grow to a large size, making surgical removal difficult. Not only that, but tumors can develop resistance to chemotherapy and suppress immune cells, making therapy even more troublesome.

CHP fluorescent staining can efficiently and selectively identify the degenerated collagen matrix at each stage in a clinical tissue array of PDAC. Such identification serves as a major advancement in the analysis of PDAC development, working to help the hundreds of thousands suffering from this disease.

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