News

Biliary Atresia (BA) is a severe liver disease in infants, often leading to cirrhosis and death. Collagen Hybridizing Peptides (CHP) offer diagnostic and prognostic insights, aiding treatment decisions and organ transplant allocation.

Explore more about the impact of obesity-related pre-diabetic hyperglycemia on bone healing using the DIO mouse model. CHPs help reveal that deficits in collagen microstructure leads to impaired fracture healing in obese subjects.

In a recently accepted article published in Bioconjugate Chemistry, researchers from the University of Utah used CHPs in an antibody-conjugate to address Rheumatoid Arthritis(RA). In this paper, the authors used the Fab region from infliximab (an anti-TNFα therapy known as Remicade®) and conjugated this with CHPs. Figure Caption.  A) Biodistribution of IR680 labeled bFab-(NIRF)CHP...

3Helix is thrilled to announce the addition of three new members to our talented team.  These new members bring with them experience and expertise that will contribute to our continued success. It is our pleasure to introduce Regan, Keelah, and Anthony to you all. Please help us congratulate them on joining our team! We...

Another great paper using CHPs! A recent article published in Wound Repair and Regeneration evaluated how the level of collagen denaturation within burned tissues influences the effectiveness of enzymatic debridement (removal of damaged tissue). They showed that low-temperature burns (<65 °C) had inadequate debridement, while high-temperature burns (>65 °C) had very effective debridement. By...

Learn more about how by utilizing CHPs, researchers studied post-IR pig heart damage. They found initial function decline, stable conditions later, and identified scar formation, corroborating Masson's Trichrome staining. No cardiomyocyte renewal observed.

Discover how Jeff Weiss's team at the University of Utah innovatively use Collagen Hybridizing Peptides to unveil tendon micro-damage mechanisms, shedding light on tendon fatigue and the crucial role that collagen triple-helix unfolding has in the human body.

Dr. Yong-Su Jin's research on Intracellular Hydroxyproline Imprinting explores collagen synthesis and degradation in resolving bleomycin-induced pulmonary fibrosis. Using CHPs, the study challenges conventional theories, suggesting that fibrosis can self-resolve, contrary to high hydroxyproline levels imply.