News

     Intervertebral disc (IVD) degeneration is a significant contributor to lower back pain, a leading cause of disability in individuals over 45. IVD is marked by the degradation of collagen and the extracellular matrix, which triggers inflammatory responses, recruits macrophages, and accelerates degeneration. Monitoring the progression of IVD degeneration and assessing the effectiveness...

     Histological staining of mouse tibia-talus joints showing healthier articular cartilage due to iFab-CHP treatment compared PBS placebo.      Rheumatoid arthritis (RA) is a chronic autoimmune disease which leads to the breakdown of the cartilage in the synovial joints. Current treatment strategies with tumor necrosis factor-alpha (TNFa)  targeting neutralizing antibodies effectively reduce...

     Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung disease marked by rapid progressive lung failure due to an accumulation of fibrotic collagen tissue. Due to the rapid onset of the disease, accurate and effective diagnostic tools are crucial for improving patient outcomes. Additionally, monitoring patient response to treatment should be minimally invasive...

Discover innovative strategies for treating osteosarcoma (OS) with localized drug delivery using Collagen Hybridizing Peptides (CHPs). OS, a malignant bone cancer, often requires surgery and chemotherapy, but these treatments are plagued by systemic side effects. This research highlights the potential of CHPs to selectively target tumors by binding to damaged collagen in bone tissue.

Atherosclerosis, characterized by the buildup of plaque inside human arteries, is one of the leading causes of cardiovascular diseases. The disease is brought on by a complex interplay between lipids, inflammatory cells, and the ECM. Arterial blood flow is restricted as plaques form, which can rupture to cause blockage. Arterial blockage, or occlusion, is...

Discover how collagen hybridizing peptides (CHPs) outperform Masson's trichrome in detecting collagen in idiopathic pulmonary fibrosis (IPF) tissues.

Discover how Collagen Hybridizing Peptides (CHPs) transform the diagnosis and treatment of cardiovascular diseases by accurately identifying and targeting damaged arterial collagen. Learn about this innovative technology and its impact on improving patient outcomes.

Collagen Hybridizing Peptides (CHPs) revolutionize liver fibrosis detection by halving biopsy analysis time. Explore detailed insights into collagen remodeling and deposition, which is directly linked to fibrotic activity.