Non-alcoholic Steatohepatitis (NASH) - 3Helix, Inc. – 3Helix Inc

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Non-alcoholic Steatohepatitis (NASH)

Table of Contents

Introduction
Current Treatment Challenges
Why CHPs?

Collagen Hybridizing Peptides allow for quantification of NASH Disease Activity

Collagen Remodeling Activity Significantly Higher in Faster Progressors of NAFLD/NASH.

When trying to identify the disease activity of NASH, there is limited information researchers have access to when determining how a patient’s fibrosis will progress. Researchers currently use stains like Picrosirius Red or Masson’s Trichrome which show the total collagen content of a slide.

By using Collagen Hybridizing Peptides (CHPs), researchers have more information to make crucial decisions. CHPs have been used to remove the heterogeneity of a patient group, clearly showing that fast progressors have a higher amount of remodeling collagen compared to the total collagen present and that slow progressors’ collagen is made up of stable scar tissue. In addition to visualizing and monitoring the progression of fibrosis, CHPs can also quantify the pauses in fibrosis in response to treatment as a secondary endpoint.

Collagen Hybridizing Peptides can Identify fibrosis in many other hepatic conditions, including but not limited to:

Liver Cirrhosis
Hepatitis
Liver Cancers (Hepatocellular Carcinoma, Cholangiocarcinoma, etc.)
Hepatic Auto-immune Conditions (PSC, PBC, etc.)

We highly recommend using our In Vivo CHPs to investigate these conditions

In Vivo Probes Histology Probes

Our In Vivo CHPs are conjugated with sCy 7.5 for near-IR detection. Contact us for customized conjugates.

Understanding Non-alcoholic Steatohepatitis (NASH)

Understanding nAMD

NASH is a type of nonalcoholic fatty liver disease(NAFLD), in which fat builds up in your liver. NASH induces inflammation and liver damage, along with fat in the liver. NASH is oftentimes a silent disease – with little to no apparent symptoms. In NASH, liver tissue is damaged to the point that it becomes replaced with scar tissue, a process known as fibrosis, which prevents the liver from working properly. NAFLD/NASH outcomes are challenging to predict due to the heterogeneity in disease progression.

Current Treatment Challenges

Currently, the only definitive method of diagnosing NASH is through a liver biopsy – which is invasive and painful. There are no FDA approved drugs to treat NASH, therefore there is nothing that can reverse fat buildup in the liver. As of now, the first line of management is simply lifestyle modifications: weight loss and increased physical activity.

CHP staining is an efficient prognostic for NASH progression. Staining remodeling collagen has displayed striking differences in fast versus slow progressors. Such CHP use will not only enable therapeutics through the FDA process, but also determine who should receive treatment once therapeutics are available.

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